Cytotoxic ent-kaurane diterpenoids from Isodon nervosus.
Chem Biodivers
; 10(8): 1487-93, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23939796
Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07 µM, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Plant Components, Aerial
/
Diterpenes, Kaurane
Limits:
Animals
/
Humans
Language:
En
Journal:
Chem Biodivers
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2013
Document type:
Article
Country of publication:
Switzerland