Chemistry, Organic/history; Endocrinology/history; Genitalia/metabolism; Neoplasm Proteins/metabolism; Neoplasms, Hormone-Dependent/metabolism; Receptors, Steroid/metabolism; Urogenital Neoplasms/metabolism; Androgen Antagonists/pharmacology; Androgen Antagonists/therapeutic use; Androgens/chemistry; Androgens/metabolism; Androgens/pharmacology; Androgens/therapeutic use; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Antineoplastic Agents, Hormonal/pharmacology; Antineoplastic Agents, Hormonal/therapeutic use; Estrogen Antagonists/pharmacology; Estrogen Antagonists/therapeutic use; Estrogens/chemistry; Estrogens/metabolism; Estrogens/pharmacology; Estrogens/therapeutic use; Female; Genitalia/drug effects; History, 20th Century; History, 21st Century; Humans; Male; Neoplasm Proteins/agonists; Neoplasm Proteins/antagonists & inhibitors; Neoplasms, Hormone-Dependent/diagnosis; Neoplasms, Hormone-Dependent/drug therapy; Neoplasms, Hormone-Dependent/history; Receptors, Steroid/agonists; Receptors, Steroid/antagonists & inhibitors; United States; Urogenital Neoplasms/diagnosis; Urogenital Neoplasms/drug therapy; Urogenital Neoplasms/history