Novel heterocyclic-fused pyrimidine derivatives: synthesis, molecular modeling and pharmacological screening.

Arafa, Reem K; Nour, Mai S; El-Sayed, Nehad A

Arafa, Reem K; Nour, Mai S; El-Sayed, Nehad A.

Affiliation

Arafa RK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address: rkarafa@cu.edu.eg.

Eur J Med Chem ; 69: 498-507, 2013 Nov.

Article in En | MEDLINE | ID: mdl-24090920

Subject(s)

Antineoplastic Agents/pharmacology; Heterocyclic Compounds/chemistry; Protein Kinase Inhibitors/pharmacology; Pyrimidines/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/chemistry; Pyrimidines/chemical synthesis; Pyrimidines/chemistry; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors; Structure-Activity Relationship; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/metabolism

Key words

Antiproliferative agents; Fused pyrimidines; MCF-7 breast cancer cell line; c-Src and VEGFR inhibition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Protein Kinase Inhibitors / Heterocyclic Compounds / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Eur J Med Chem Year: 2013 Document type: Article Country of publication: France

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