Chronic exposure to valproic acid promotes insulin release, reduces KATP channel current and does not affect Ca (2+) signaling in mouse islets.

Manaka, Kazunori; Nakata, Masanori; Shimomura, Kenju; Rita, Rauza S; Maejima, Yuko; Yoshida, Masashi; Dezaki, Katsuya; Kakei, Masafumi; Yada, Toshihiko

Manaka, Kazunori; Nakata, Masanori; Shimomura, Kenju; Rita, Rauza S; Maejima, Yuko; Yoshida, Masashi; Dezaki, Katsuya; Kakei, Masafumi; Yada, Toshihiko.

Affiliation

Manaka K; Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Yakushiji 3311-1, Shimotsuke, Tochigi, 329-0498, Japan.

J Physiol Sci ; 64(1): 77-83, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24105600

Subject(s)

Calcium Signaling/drug effects; Insulin/metabolism; Islets of Langerhans/metabolism; KATP Channels/metabolism; Valproic Acid/pharmacology; Animals; Islets of Langerhans/drug effects; KATP Channels/drug effects; Male; Mice; Models, Animal; Patch-Clamp Techniques; Potassium Channel Blockers/pharmacology; Tolbutamide/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Valproic Acid / Calcium Signaling / KATP Channels / Insulin Limits: Animals Language: En Journal: J Physiol Sci Journal subject: FISIOLOGIA / TRAUMATOLOGIA Year: 2014 Document type: Article Affiliation country: Japan

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