Effect of change in spindle structure on proliferation inhibition of osteosarcoma cells and osteoblast under simulated microgravity during incubation in rotating bioreactor.

Wei, Lijun; Diao, Yan; Qi, Jing; Khokhlov, Alexander; Feng, Hui; Yan, Xing; Li, Yu

Wei, Lijun; Diao, Yan; Qi, Jing; Khokhlov, Alexander; Feng, Hui; Yan, Xing; Li, Yu.

Affiliation

Wei L; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

PLoS One ; 8(10): e76710, 2013.

Article in En | MEDLINE | ID: mdl-24116140

Subject(s)

Bioreactors; Cell Proliferation; Osteoblasts/metabolism; Spindle Apparatus/physiology; Weightlessness Simulation; Animals; Apoptosis/physiology; Blotting, Western; Cell Cycle Checkpoints/physiology; Cell Line; Cell Line, Tumor; Cells, Cultured; Centrosome/physiology; DNA/genetics; DNA/metabolism; Flow Cytometry; Humans; Mad2 Proteins/genetics; Mad2 Proteins/metabolism; Mitotic Index; Osteoblasts/cytology; Osteosarcoma/metabolism; Osteosarcoma/pathology; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; RNA Interference; Rats; Rotation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Weightlessness Simulation / Bioreactors / Cell Proliferation / Spindle Apparatus Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: China Country of publication: United States

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