Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to ß-lactams.

Mondon, Martine; Hur, Soo; Vadlamani, Grishma; Rodrigues, Prerana; Tsybina, Polina; Oliver, Antonio; Mark, Brian L; Vocadlo, David J; Blériot, Yves

Mondon, Martine; Hur, Soo; Vadlamani, Grishma; Rodrigues, Prerana; Tsybina, Polina; Oliver, Antonio; Mark, Brian L; Vocadlo, David J; Blériot, Yves.

Affiliation

Mondon M; Université de Poitiers, IC2MP, UMR CNRS 7285, Équipe "Synthése Organique" Groupe Glycochimie, 4 rue Michel Brunet, 86022 Poitiers Cedex, France. yves.bleriot@univ-poitiers.fr.

Chem Commun (Camb) ; 49(93): 10983-5, 2013 Dec 04.

Article in En | MEDLINE | ID: mdl-24136176

Subject(s)

Acetylglucosaminidase/antagonists & inhibitors; Anti-Bacterial Agents/chemistry; Azepines/chemistry; Bacterial Proteins/antagonists & inhibitors; Enzyme Inhibitors/chemistry; Pseudomonas aeruginosa/enzymology; beta-Lactams/chemistry; Acetylglucosaminidase/metabolism; Anti-Bacterial Agents/pharmacology; Azepines/pharmacology; Bacterial Proteins/metabolism; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Bacterial/drug effects; Enzyme Inhibitors/pharmacology; Hydrogen Bonding; Pseudomonas aeruginosa/drug effects; beta-Lactamases/metabolism; beta-Lactams/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Acetylglucosaminidase / Azepines / Bacterial Proteins / Beta-Lactams / Enzyme Inhibitors / Anti-Bacterial Agents Type of study: Diagnostic_studies Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: France Country of publication: United kingdom

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