The involvement of PI3K-mediated and L-VGCC-gated transient Ca2+ influx in 17ß-estradiol-mediated protection of retinal cells from H2O2-induced apoptosis with Ca2+ overload.

Feng, Yan; Wang, Baoying; Du, Fangying; Li, Hongbo; Wang, Shaolan; Hu, Chenghu; Zhu, Chunhui; Yu, Xiaorui

Feng, Yan; Wang, Baoying; Du, Fangying; Li, Hongbo; Wang, Shaolan; Hu, Chenghu; Zhu, Chunhui; Yu, Xiaorui.

Affiliation

Feng Y; Department of Genetics and Molecular Biology, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

PLoS One ; 8(11): e77218, 2013.

Article in En | MEDLINE | ID: mdl-24223708

Subject(s)

Apoptosis; Calcium Channels, L-Type/metabolism; Calcium Signaling; Estradiol/pharmacology; Hydrogen Peroxide/pharmacology; Neuroprotective Agents/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Animals; Calcium Channel Blockers/pharmacology; Cell Survival/drug effects; Cells, Cultured; Chromones/pharmacology; Cytoprotection; Morpholines/pharmacology; Nifedipine/pharmacology; Oxidants/pharmacology; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Retinal Neurons/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Neuroprotective Agents / Phosphatidylinositol 3-Kinases / Calcium Signaling / Calcium Channels, L-Type / Estradiol / Hydrogen Peroxide Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: China

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