Traumatic brain injury precipitates cognitive impairment and extracellular Aß aggregation in Alzheimer's disease transgenic mice.

Tajiri, Naoki; Kellogg, S Leilani; Shimizu, Toru; Arendash, Gary W; Borlongan, Cesar V

Tajiri, Naoki; Kellogg, S Leilani; Shimizu, Toru; Arendash, Gary W; Borlongan, Cesar V.

Affiliation

Tajiri N; Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America.

PLoS One ; 8(11): e78851, 2013.

Article in En | MEDLINE | ID: mdl-24223856

Subject(s)

Alzheimer Disease/physiopathology; Amyloid beta-Peptides/metabolism; Brain Injuries/physiopathology; Cognition Disorders/physiopathology; Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Animals; Brain Injuries/complications; Cognition Disorders/etiology; Disease Models, Animal; Extracellular Space/metabolism; Hippocampus/injuries; Hippocampus/metabolism; Humans; Maze Learning/physiology; Memory/physiology; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Transgenic; Microscopy, Confocal; Parietal Lobe/injuries; Parietal Lobe/metabolism; Presenilin-1/genetics; Presenilin-1/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Amyloid beta-Peptides / Cognition Disorders / Alzheimer Disease Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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