A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust.

Manners, Sarah; Alam, Rafeul; Schwartz, David A; Gorska, Magdalena M

Manners, Sarah; Alam, Rafeul; Schwartz, David A; Gorska, Magdalena M.

Affiliation

Manners S; Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health, Denver, Colo.
Alam R; Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health, Denver, Colo; Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado Denver, Aurora, Colo.
Schwartz DA; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colo.
Gorska MM; Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health, Denver, Colo; Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado Denver, Aurora, Colo. Electronic address: gorskam@njhealth.org.

J Allergy Clin Immunol ; 134(1): 63-72, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24365139

Subject(s)

Air Pollutants/toxicity; Asthma/immunology; Bronchial Hyperreactivity/immunology; Killer Cells, Natural/immunology; Prenatal Exposure Delayed Effects/immunology; Vehicle Emissions/toxicity; Animals; Asthma/etiology; Asthma/genetics; Asthma/pathology; Bronchial Hyperreactivity/etiology; Bronchial Hyperreactivity/genetics; Bronchial Hyperreactivity/pathology; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Immunoglobulin E/genetics; Immunoglobulin E/immunology; Interleukin-17/genetics; Interleukin-17/immunology; Killer Cells, Natural/pathology; Maternal Exposure/adverse effects; Mice; Mice, Inbred C57BL; Ovalbumin/administration & dosage; Pregnancy; Prenatal Exposure Delayed Effects/genetics; Prenatal Exposure Delayed Effects/pathology; Receptors, Aryl Hydrocarbon/genetics; Receptors, Aryl Hydrocarbon/immunology; Transcription, Genetic

Key words

IL-13; IL-17; IL-5; Prenatal exposure; aryl hydrocarbon receptor; asthma; diesel exhaust particles; mouse model; natural killer cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Asthma / Vehicle Emissions / Killer Cells, Natural / Bronchial Hyperreactivity / Air Pollutants Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: J Allergy Clin Immunol Year: 2014 Document type: Article

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