Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²âº channel due to a familial hemiplegic migraine mutation.

Inagaki, Akira; Frank, C Andrew; Usachev, Yuriy M; Benveniste, Morris; Lee, Amy

Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²âº channel due to a familial hemiplegic migraine mutation.

Inagaki, Akira; Frank, C Andrew; Usachev, Yuriy M; Benveniste, Morris; Lee, Amy.

Affiliation

Inagaki A; Department of Molecular Physiology & Biophysics, Department of Otolaryngology-Head and Neck Surgery, and Department of Neurology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA.
Frank CA; Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA.
Usachev YM; Department of Pharmacology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA.
Benveniste M; Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA 30310, USA.
Lee A; Department of Molecular Physiology & Biophysics, Department of Otolaryngology-Head and Neck Surgery, and Department of Neurology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA. Electronic address: amy-lee@uiowa.edu.

Neuron ; 81(1): 91-102, 2014 Jan 08.

Article in En | MEDLINE | ID: mdl-24411734

Subject(s)

Calcium Channels, N-Type/genetics; Calcium Channels/drug effects; Membrane Potentials/drug effects; Migraine with Aura/genetics; Mutation/genetics; Quinones/pharmacology; Animals; Animals, Genetically Modified; Biophysical Phenomena/drug effects; Biophysical Phenomena/genetics; Biophysics; Calcium/metabolism; Calcium Channels/genetics; Computer Simulation; Disease Models, Animal; Drosophila; Excitatory Postsynaptic Potentials/drug effects; Excitatory Postsynaptic Potentials/genetics; Green Fluorescent Proteins/genetics; HEK293 Cells; Humans; Intracellular Fluid/drug effects; Lysine/genetics; Membrane Potentials/genetics; Migraine with Aura/drug therapy; Migraine with Aura/pathology; Models, Biological; Neuromuscular Junction/drug effects; Neuromuscular Junction/genetics; Patch-Clamp Techniques; Serine/genetics; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinones / Calcium Channels / Migraine with Aura / Calcium Channels, N-Type / Membrane Potentials / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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