Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

Ghetie, M A; May, R D; Till, M; Uhr, J W; Ghetie, V; Knowles, P P; Relf, M; Brown, A; Wallace, P M; Janossy, G

Ghetie, M A; May, R D; Till, M; Uhr, J W; Ghetie, V; Knowles, P P; Relf, M; Brown, A; Wallace, P M; Janossy, G.

Affiliation

Ghetie MA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.

Cancer Res ; 48(9): 2610-7, 1988 May 01.

Article in En | MEDLINE | ID: mdl-2451562

Subject(s)

Antigens, CD; Antigens, Differentiation, B-Lymphocyte/immunology; Antigens, Surface/immunology; B-Lymphocytes/immunology; Cell Adhesion Molecules; Immunotoxins/pharmacology; Lectins; Leukemia/therapy; Lymphoma/therapy; Ricin/pharmacology; Antigens, CD19; B-Lymphocytes/drug effects; Cell Line; Clinical Trials as Topic; Cytotoxicity, Immunologic; Humans; Immunoglobulin Fab Fragments/immunology; Immunotoxins/therapeutic use; Leukemia/immunology; Lymphoma/immunology; Ricin/therapeutic use; Sialic Acid Binding Ig-like Lectin 2; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Ricin / B-Lymphocytes / Leukemia / Antigens, Differentiation, B-Lymphocyte / Antigens, CD / Cell Adhesion Molecules / Immunotoxins / Lectins / Lymphoma / Antigens, Surface Limits: Humans Language: En Journal: Cancer Res Year: 1988 Document type: Article Country of publication: United States

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