Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions.

Aursnes, Marius; Tungen, Jørn E; Vik, Anders; Colas, Romain; Cheng, Chien-Yee C; Dalli, Jesmond; Serhan, Charles N; Hansen, Trond V

Aursnes, Marius; Tungen, Jørn E; Vik, Anders; Colas, Romain; Cheng, Chien-Yee C; Dalli, Jesmond; Serhan, Charles N; Hansen, Trond V.

Affiliation

Aursnes M; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo , PO Box 1068, Blindern, N-0316 Oslo, Norway.

J Nat Prod ; 77(4): 910-6, 2014 Apr 25.

Article in En | MEDLINE | ID: mdl-24576195

Subject(s)

Anti-Inflammatory Agents/chemical synthesis; Anti-Inflammatory Agents/pharmacology; Eicosapentaenoic Acid/metabolism; Fatty Acids, Unsaturated/chemistry; Animals; Anti-Inflammatory Agents/chemistry; Chromatography, Liquid; Docosahexaenoic Acids/chemistry; Docosahexaenoic Acids/pharmacology; Eicosapentaenoic Acid/analogs & derivatives; Eicosapentaenoic Acid/chemistry; Eicosapentaenoic Acid/pharmacology; Humans; Macrophages/metabolism; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Eicosapentaenoic Acid / Fatty Acids, Unsaturated / Anti-Inflammatory Agents Limits: Animals / Humans Language: En Journal: J Nat Prod Year: 2014 Document type: Article Affiliation country: Norway Country of publication: United States

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