Zinc supplementation alleviates diabetic peripheral neuropathy by inhibiting oxidative stress and upregulating metallothionein in peripheral nerves of diabetic rats.

Liu, Fangyao; Ma, Feiyu; Kong, Gengbin; Wu, Kezhou; Deng, Zhihua; Wang, Hu

Liu, Fangyao; Ma, Feiyu; Kong, Gengbin; Wu, Kezhou; Deng, Zhihua; Wang, Hu.

Affiliation

Liu F; Department of Orthopaedics, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.

Biol Trace Elem Res ; 158(2): 211-8, 2014 May.

Article in En | MEDLINE | ID: mdl-24615552

Subject(s)

Diabetes Mellitus, Experimental/drug therapy; Diabetic Neuropathies/drug therapy; Metallothionein/metabolism; Oxidative Stress/drug effects; Peripheral Nerves/drug effects; Up-Regulation/drug effects; Zinc/pharmacology; Animals; Diabetes Mellitus, Experimental/chemically induced; Diabetes Mellitus, Experimental/metabolism; Diabetic Neuropathies/chemically induced; Diabetic Neuropathies/metabolism; Dietary Supplements; Dose-Response Relationship, Drug; Male; Peripheral Nerves/metabolism; Rats; Rats, Sprague-Dawley; Streptozocin; Zinc/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peripheral Nerves / Zinc / Up-Regulation / Oxidative Stress / Diabetes Mellitus, Experimental / Diabetic Neuropathies / Metallothionein Limits: Animals Language: En Journal: Biol Trace Elem Res Year: 2014 Document type: Article Affiliation country: China Country of publication: United States

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