Reduced 64Cu uptake and tumor growth inhibition by knockdown of human copper transporter 1 in xenograft mouse model of prostate cancer.

Cai, Huawei; Wu, Jiu-sheng; Muzik, Otto; Hsieh, Jer-Tsong; Lee, Robert J; Peng, Fangyu

Cai, Huawei; Wu, Jiu-sheng; Muzik, Otto; Hsieh, Jer-Tsong; Lee, Robert J; Peng, Fangyu.

Affiliation

Cai H; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.

J Nucl Med ; 55(4): 622-8, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24639459

Subject(s)

Cation Transport Proteins/therapeutic use; Copper/metabolism; Prostatic Neoplasms/metabolism; Animals; Blotting, Western; Cation Transport Proteins/genetics; Cell Line, Tumor; Cell Proliferation; Copper Radioisotopes; Copper Transporter 1; Genetic Vectors; Humans; Lentivirus/genetics; Male; Mice; Positron-Emission Tomography; Prostatic Neoplasms/diagnostic imaging; RNA, Small Interfering/genetics; Radiopharmaceuticals; Tissue Distribution; Xenograft Model Antitumor Assays

Key words

64Cu-chloride; PET/CT; copper metabolism; human copper transporter 1; prostate cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Copper / Cation Transport Proteins Limits: Animals / Humans / Male Language: En Journal: J Nucl Med Year: 2014 Document type: Article

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