Homocysteine exacerbates ß-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.

Li, Jian-Guo; Chu, Jin; Barrero, Carlos; Merali, Salim; Praticò, Domenico

Li, Jian-Guo; Chu, Jin; Barrero, Carlos; Merali, Salim; Praticò, Domenico.

Affiliation

Li JG; Department of Pharmacology and Center for Translational Medicine, School of Medicine, Temple University, Philadelphia, PA.

Ann Neurol ; 75(6): 851-63, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24644038

Subject(s)

Alzheimer Disease; Amyloid beta-Peptides/metabolism; Cognition Disorders/etiology; Homocysteine/metabolism; tau Proteins/metabolism; Alzheimer Disease/complications; Alzheimer Disease/etiology; Alzheimer Disease/genetics; Amyloid beta-Protein Precursor/genetics; Animals; Brain/metabolism; Cell Line, Tumor; Diet/adverse effects; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation/genetics; Neuroblastoma/pathology; Neurofibrillary Tangles/metabolism; Plaque, Amyloid/complications; Presenilin-1/genetics; Signal Transduction/physiology; tau Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Tau Proteins / Cognition Disorders / Alzheimer Disease / Homocysteine Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Ann Neurol Year: 2014 Document type: Article Affiliation country: Panama Country of publication: United States

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