Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption.

Sekar, Revathi; Chow, Billy K C

Sekar, Revathi; Chow, Billy K C.

Affiliation

Sekar R; School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
Chow BK; School of Biological Sciences, The University of Hong Kong, Hong Kong, China bkcc@hku.hk.

FASEB J ; 28(8): 3494-505, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24769669

Subject(s)

Diet, High-Fat/adverse effects; Dietary Fats/pharmacokinetics; Intestinal Absorption/genetics; Obesity/genetics; Receptors, G-Protein-Coupled/physiology; Receptors, Gastrointestinal Hormone/physiology; Secretin/physiology; Adiposity/genetics; Adiposity/physiology; Animals; CD36 Antigens/physiology; Carrier Proteins/physiology; Energy Metabolism; Enterocytes/metabolism; Feedback, Physiological; Female; Glucose Tolerance Test; Insulin Resistance; Jejunum/metabolism; Leptin/blood; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity/blood; Obesity/etiology; Obesity/physiopathology; Receptors, G-Protein-Coupled/deficiency; Receptors, Gastrointestinal Hormone/deficiency; Triglycerides/blood; Weight Gain

Key words

CD36; enterocytes; long chain fatty acid; positive feedback loop; postprandial triglyceride release

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Gastrointestinal Hormone / Secretin / Dietary Fats / Receptors, G-Protein-Coupled / Diet, High-Fat / Intestinal Absorption / Obesity Type of study: Etiology_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2014 Document type: Article Affiliation country: China Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google