Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII&#945; as anti-tumor strategy.

Li, Jiangmei; Zhang, Lunfeng; Gao, Zhen; Kang, Hua; Rong, Guohua; Zhang, Xu; Chen, Chang

Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy.

Li, Jiangmei; Zhang, Lunfeng; Gao, Zhen; Kang, Hua; Rong, Guohua; Zhang, Xu; Chen, Chang.

Affiliation

Li J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Protein Cell ; 5(6): 457-68, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24801752

Subject(s)

ErbB Receptors/metabolism; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Animals; Antineoplastic Agents/pharmacology; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Survival/drug effects; ErbB Receptors/antagonists & inhibitors; Female; HSP90 Heat-Shock Proteins/metabolism; Humans; MCF-7 Cells; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Minor Histocompatibility Antigens; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors; Phosphotransferases (Alcohol Group Acceptor)/genetics; Proto-Oncogene Proteins c-akt/metabolism; Quinazolines/pharmacology; Transplantation, Heterologous; Tyrphostins/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphotransferases (Alcohol Group Acceptor) / ErbB Receptors Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Protein Cell Journal subject: BIOQUIMICA Year: 2014 Document type: Article Affiliation country: China Country of publication: Germany

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