Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS).

Moorthy, Balakrishnan S; Schultz, Steven G; Kim, Sherry G; Topp, Elizabeth M

Moorthy, Balakrishnan S; Schultz, Steven G; Kim, Sherry G; Topp, Elizabeth M.

Affiliation

Moorthy BS; Purdue University , West Lafayette, Indiana 47907, United States.

Mol Pharm ; 11(6): 1869-79, 2014 Jun 02.

Article in En | MEDLINE | ID: mdl-24816133

Subject(s)

Amides/chemistry; Deuterium/chemistry; Hydrogen/chemistry; Protein Aggregates/physiology; Proteins/chemistry; Chemistry, Pharmaceutical/methods; Excipients/chemistry; Freeze Drying/methods; Kinetics; Mannitol/chemistry; Mass Spectrometry/methods; Myoglobin/chemistry; Sodium Chloride/chemistry; Sucrose/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Deuterium / Protein Aggregates / Amides / Hydrogen Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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