Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry.

Huo, Shuaidong; Jin, Shubin; Ma, Xiaowei; Xue, Xiangdong; Yang, Keni; Kumar, Anil; Wang, Paul C; Zhang, Jinchao; Hu, Zhongbo; Liang, Xing-Jie

Huo, Shuaidong; Jin, Shubin; Ma, Xiaowei; Xue, Xiangdong; Yang, Keni; Kumar, Anil; Wang, Paul C; Zhang, Jinchao; Hu, Zhongbo; Liang, Xing-Jie.

Affiliation

Huo S; Chinese Academy of Sciences (CAS) Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11, First North Road, Zhongguancun, Beijing, China 100190.

ACS Nano ; 8(6): 5852-62, 2014 Jun 24.

Article in En | MEDLINE | ID: mdl-24824865

Subject(s)

Breast Neoplasms/therapy; Cell Nucleus/metabolism; Genetic Therapy/methods; Gold/chemistry; Metal Nanoparticles/chemistry; Nanotechnology/methods; Cell Survival; Cytoplasm/metabolism; Female; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Vectors; Humans; MCF-7 Cells; Oligonucleotides/chemistry; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc/chemistry; RNA/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Genetic Therapy / Cell Nucleus / Nanotechnology / Metal Nanoparticles / Gold Type of study: Guideline Limits: Female / Humans Language: En Journal: ACS Nano Year: 2014 Document type: Article Country of publication: United States

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