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Axillary metastasis from an occult tubal serous carcinoma in a patient with ipsilateral breast carcinoma: a potential diagnostic pitfall.
Atallah, Chantal; Altinel, Gulbeyaz; Fu, Lili; Arseneau, Jocelyne; Omeroglu, Atilla.
Affiliation
  • Atallah C; McGill University Health Center, Montreal, QC, Canada H3A 1A1.
  • Altinel G; McGill University Health Center, Montreal, QC, Canada H3A 1A1.
  • Fu L; McGill University Health Center, Montreal, QC, Canada H3A 1A1.
  • Arseneau J; McGill University Health Center, Montreal, QC, Canada H3A 1A1.
  • Omeroglu A; McGill University Health Center, Montreal, QC, Canada H3A 1A1.
Case Rep Pathol ; 2014: 534034, 2014.
Article in En | MEDLINE | ID: mdl-25110596
Axillary nodal metastasis from a nonmammary neoplasia is much rarer than diseases associated with a primary breast carcinoma. However, this has to be considered in the differential diagnosis of nodal disease in patients with a history of breast cancer. Here, we report the case of a 73-year-old female with a past medical history of breast cancer, presenting with an ipsilateral axillary metastatic carcinoma. The immunohistochemical profile of the metastatic lesion was consistent with a high grade serous carcinoma. After undergoing a total abdominal hysterectomy and salpingo-oophorectomy, thorough pathological examination revealed two microscopic foci of serous carcinoma in the right fallopian tube, not detectable by preoperative magnetic resonance imaging. In this context, the poorly differentiated appearance of the metastatic tumor and positive staining for estrogen receptor, might lead to a misdiagnosis of metastatic breast carcinoma. As the therapeutic implications differ, it is important for the pathologist to critically assess axillary lymph node metastases, even in patients with a past history of ipsilateral breast carcinoma and no other known primary tumors.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: Case Rep Pathol Year: 2014 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: Case Rep Pathol Year: 2014 Document type: Article Country of publication: United States