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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.
Lundberg, Pontus; Takizawa, Hitoshi; Kubovcakova, Lucia; Guo, Guoji; Hao-Shen, Hui; Dirnhofer, Stephan; Orkin, Stuart H; Manz, Markus G; Skoda, Radek C.
Affiliation
  • Lundberg P; Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
  • Takizawa H; Division of Hematology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
  • Kubovcakova L; Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
  • Guo G; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02215.
  • Hao-Shen H; Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland.
  • Dirnhofer S; Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
  • Orkin SH; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02215.
  • Manz MG; Division of Hematology, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.
  • Skoda RC; Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland radek.skoda@unibas.ch.
J Exp Med ; 211(11): 2213-30, 2014 Oct 20.
Article in En | MEDLINE | ID: mdl-25288396
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Cell Transformation, Neoplastic / Janus Kinase 2 / Mutation / Myeloproliferative Disorders Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Exp Med Year: 2014 Document type: Article Affiliation country: Switzerland Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Cell Transformation, Neoplastic / Janus Kinase 2 / Mutation / Myeloproliferative Disorders Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Exp Med Year: 2014 Document type: Article Affiliation country: Switzerland Country of publication: United States