Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions.

Obinata, Hideru; Gutkind, Sarah; Stitham, Jeremiah; Okuno, Toshiaki; Yokomizo, Takehiko; Hwa, John; Hla, Timothy

Obinata, Hideru; Gutkind, Sarah; Stitham, Jeremiah; Okuno, Toshiaki; Yokomizo, Takehiko; Hwa, John; Hla, Timothy.

Affiliation

Obinata H; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065.
Gutkind S; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065.
Stitham J; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Okuno T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Yokomizo T; Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Hwa J; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Hla T; Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065.

J Lipid Res ; 55(12): 2665-75, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25293589

Subject(s)

Coronary Artery Disease/genetics; Endocytosis/drug effects; Immunosuppressive Agents/pharmacology; Lysophospholipids/metabolism; Polymorphism, Single Nucleotide; Receptors, Lysosphingolipid/genetics; Signal Transduction; Sphingosine/analogs & derivatives; Aged; Animals; Case-Control Studies; Cell Line; Cells, Cultured; Coronary Artery Disease/metabolism; Cricetulus; Drug Resistance; Female; Fingolimod Hydrochloride; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutant Proteins/metabolism; Propylene Glycols/pharmacology; Receptors, Lysosphingolipid/agonists; Receptors, Lysosphingolipid/antagonists & inhibitors; Receptors, Lysosphingolipid/metabolism; Recombinant Fusion Proteins/metabolism; Signal Transduction/drug effects; Sphingosine/metabolism; Sphingosine/pharmacology; Sphingosine-1-Phosphate Receptors

Key words

cell signaling; drug therapy; endocytosis; genetics; single nucleotide polymorphism; sphingosine 1-phosphate receptor; sphingosine phosphate

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingosine / Coronary Artery Disease / Lysophospholipids / Signal Transduction / Polymorphism, Single Nucleotide / Receptors, Lysosphingolipid / Endocytosis / Immunosuppressive Agents Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Lipid Res Year: 2014 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google