Organocatalytic and scalable synthesis of the anti-influenza drugs zanamivir, laninamivir, and CS-8958.

Tian, Junshan; Zhong, Jiankang; Li, Yunsheng; Ma, Dawei

Tian, Junshan; Zhong, Jiankang; Li, Yunsheng; Ma, Dawei.

Affiliation

Tian J; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 (China).

Angew Chem Int Ed Engl ; 53(50): 13885-8, 2014 Dec 08.

Article in En | MEDLINE | ID: mdl-25314609

Subject(s)

Antiviral Agents/chemical synthesis; Zanamivir/analogs & derivatives; Zanamivir/chemical synthesis; Antiviral Agents/therapeutic use; Catalysis; Guanidines; Humans; Influenza, Human/drug therapy; Pyrans; Sialic Acids; Zanamivir/therapeutic use

Key words

anti-influenza drugs; asymmetric catalysis; organocatalysis; scalable synthesis; total synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Zanamivir Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2014 Document type: Article Country of publication: Germany

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