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Clonal outbreak of Plasmodium falciparum infection in eastern Panama.
Obaldia, Nicanor; Baro, Nicholas K; Calzada, Jose E; Santamaria, Ana M; Daniels, Rachel; Wong, Wesley; Chang, Hsiao-Han; Hamilton, Elizabeth J; Arevalo-Herrera, Myriam; Herrera, Socrates; Wirth, Dyann F; Hartl, Daniel L; Marti, Matthias; Volkman, Sarah K.
Affiliation
  • Obaldia N; Department of Immunology and Infectious Diseases.
  • Baro NK; Department of Immunology and Infectious Diseases.
  • Calzada JE; Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City, Panama.
  • Santamaria AM; Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City, Panama.
  • Daniels R; Department of Organismic and Evolutionary Biology, Harvard University.
  • Wong W; Department of Immunology and Infectious Diseases.
  • Chang HH; Department of Epidemiology, Harvard School of Public Health.
  • Hamilton EJ; Department of Immunology and Infectious Diseases.
  • Arevalo-Herrera M; Centro de Investigación Científica Caucaseco/Centro Latino Americano de Investigación en Malaria, Cali, Colombia.
  • Herrera S; Centro de Investigación Científica Caucaseco/Centro Latino Americano de Investigación en Malaria, Cali, Colombia.
  • Wirth DF; Department of Immunology and Infectious Diseases Broad Institute, Cambridge, Massachusetts.
  • Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University.
  • Marti M; Department of Immunology and Infectious Diseases.
  • Volkman SK; Department of Immunology and Infectious Diseases Simmons College, Boston Broad Institute, Cambridge, Massachusetts.
J Infect Dis ; 211(7): 1087-96, 2015 Apr 01.
Article in En | MEDLINE | ID: mdl-25336725
Identifying the source of resurgent parasites is paramount to a strategic, successful intervention for malaria elimination. Although the malaria incidence in Panama is low, a recent outbreak resulted in a 6-fold increase in reported cases. We hypothesized that parasites sampled from this epidemic might be related and exhibit a clonal population structure. We tested the genetic relatedness of parasites, using informative single-nucleotide polymorphisms and drug resistance loci. We found that parasites were clustered into 3 clonal subpopulations and were related to parasites from Colombia. Two clusters of Panamanian parasites shared identical drug resistance haplotypes, and all clusters shared a chloroquine-resistance genotype matching the pfcrt haplotype of Colombian origin. Our findings suggest these resurgent parasite populations are highly clonal and that the high clonality likely resulted from epidemic expansion of imported or vestigial cases. Malaria outbreak investigations that use genetic tools can illuminate potential sources of epidemic malaria and guide strategies to prevent further resurgence in areas where malaria has been eliminated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Drug Resistance / Chloroquine / Disease Outbreaks / Malaria, Falciparum / Antimalarials Type of study: Prognostic_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Country/Region as subject: America central / America do sul / Colombia / Panama Language: En Journal: J Infect Dis Year: 2015 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Drug Resistance / Chloroquine / Disease Outbreaks / Malaria, Falciparum / Antimalarials Type of study: Prognostic_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Country/Region as subject: America central / America do sul / Colombia / Panama Language: En Journal: J Infect Dis Year: 2015 Document type: Article Country of publication: United States