Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents.

Bernard-Gauthier, Vadim; Aliaga, Arturo; Aliaga, Antonio; Boudjemeline, Mehdi; Hopewell, Robert; Kostikov, Alexey; Rosa-Neto, Pedro; Thiel, Alexander; Schirrmacher, Ralf

Bernard-Gauthier, Vadim; Aliaga, Arturo; Aliaga, Antonio; Boudjemeline, Mehdi; Hopewell, Robert; Kostikov, Alexey; Rosa-Neto, Pedro; Thiel, Alexander; Schirrmacher, Ralf.

Affiliation

Bernard-Gauthier V; Experimental Medicine, Department of Medicine, McGill University , 1110 Pine Avenue West, Montreal, Quebec H3A 1A3, Canada.

ACS Chem Neurosci ; 6(2): 260-76, 2015 Feb 18.

Article in En | MEDLINE | ID: mdl-25350780

Subject(s)

Positron-Emission Tomography/methods; Protein Kinase Inhibitors/chemical synthesis; Radiopharmaceuticals/chemical synthesis; Animals; Autoradiography; Brain/diagnostic imaging; Brain/metabolism; Carbon Radioisotopes; Drug Design; Drug Evaluation; Fluorine Radioisotopes; Humans; Indoles/chemical synthesis; Membrane Glycoproteins/antagonists & inhibitors; Membrane Glycoproteins/metabolism; Molecular Docking Simulation; Molecular Structure; Neuroblastoma/diagnostic imaging; Neuroblastoma/metabolism; Photochemical Processes; Protein-Tyrosine Kinases/antagonists & inhibitors; Protein-Tyrosine Kinases/metabolism; Pyrrolidines/chemical synthesis; Quinolines/chemical synthesis; Rats, Sprague-Dawley; Receptor, trkB

Key words

Tropomyosin receptor kinases; aza-oxindole; brain imaging; carbon-11; fluorine-18; imaging; neuroblastoma; positron emission tomography; radiochemistry; tyrosine kinase inhibitor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiopharmaceuticals / Protein Kinase Inhibitors / Positron-Emission Tomography Type of study: Evaluation_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2015 Document type: Article Affiliation country: Canada Country of publication: United States

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