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Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy.
Jonnalagadda, Mahesh; Mardiros, Armen; Urak, Ryan; Wang, Xiuli; Hoffman, Lauren J; Bernanke, Alyssa; Chang, Wen-Chung; Bretzlaff, William; Starr, Renate; Priceman, Saul; Ostberg, Julie R; Forman, Stephen J; Brown, Christine E.
Affiliation
  • Jonnalagadda M; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Mardiros A; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Urak R; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Wang X; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Hoffman LJ; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Bernanke A; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Chang WC; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Bretzlaff W; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Starr R; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Priceman S; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Ostberg JR; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Forman SJ; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
  • Brown CE; Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
Mol Ther ; 23(4): 757-68, 2015 Apr.
Article in En | MEDLINE | ID: mdl-25366031
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Antigen / Receptors, Fc / T-Lymphocytes / Mutant Chimeric Proteins / Mutation / Neoplasms, Experimental Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Antigen / Receptors, Fc / T-Lymphocytes / Mutant Chimeric Proteins / Mutation / Neoplasms, Experimental Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States