Creatine inhibits adipogenesis by downregulating insulin-induced activation of the phosphatidylinositol 3-kinase signaling pathway.

Lee, Nayeon; Kim, Inhee; Park, Soojeong; Han, Dasol; Ha, Soobong; Kwon, Mookwang; Kim, Juwan; Byun, Sung-Hyun; Oh, Wonil; Jeon, Hong Bae; Kweon, Dae-Hyuk; Cho, Jae Youl; Yoon, Keejung

Lee, Nayeon; Kim, Inhee; Park, Soojeong; Han, Dasol; Ha, Soobong; Kwon, Mookwang; Kim, Juwan; Byun, Sung-Hyun; Oh, Wonil; Jeon, Hong Bae; Kweon, Dae-Hyuk; Cho, Jae Youl; Yoon, Keejung.

Affiliation

Lee N; 1 College of Biotechnology and Bioengineering, Sungkyunkwan University , Suwon, Gyeonggi-Do, Republic of Korea.

Stem Cells Dev ; 24(8): 983-94, 2015 Apr 15.

Article in En | MEDLINE | ID: mdl-25428599

Subject(s)

Adipogenesis; Creatine/pharmacology; Down-Regulation; Mesenchymal Stem Cells/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Signal Transduction; 3T3 Cells; Animals; CCAAT-Enhancer-Binding Protein-alpha/genetics; CCAAT-Enhancer-Binding Protein-alpha/metabolism; Cells, Cultured; Complement Factor D/genetics; Complement Factor D/metabolism; Fatty Acid-Binding Proteins/genetics; Fatty Acid-Binding Proteins/metabolism; Glucose Transporter Type 1/genetics; Glucose Transporter Type 1/metabolism; Glucose Transporter Type 4/genetics; Glucose Transporter Type 4/metabolism; Humans; Insulin/pharmacology; Male; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/metabolism; Mice; Mice, Inbred C57BL; PPAR gamma/genetics; PPAR gamma/metabolism; Triglycerides/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Down-Regulation / Phosphatidylinositol 3-Kinases / Creatine / Adipogenesis / Mesenchymal Stem Cells Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Stem Cells Dev Journal subject: HEMATOLOGIA Year: 2015 Document type: Article Country of publication: United States

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