Backbone cyclization of a recombinant cystine-knot peptide by engineered Sortase A.

Stanger, Karen; Maurer, Till; Kaluarachchi, Harini; Coons, Mary; Franke, Yvonne; Hannoush, Rami N

Stanger, Karen; Maurer, Till; Kaluarachchi, Harini; Coons, Mary; Franke, Yvonne; Hannoush, Rami N.

Affiliation

Stanger K; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.

FEBS Lett ; 588(23): 4487-96, 2014 Nov 28.

Article in En | MEDLINE | ID: mdl-25448598

Subject(s)

Aminoacyltransferases/metabolism; Bacterial Proteins/metabolism; Cysteine Endopeptidases/metabolism; Cystine/chemistry; Peptides, Cyclic/chemistry; Peptides, Cyclic/metabolism; Protein Engineering; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Amino Acid Sequence; Aminoacyltransferases/chemistry; Aminoacyltransferases/genetics; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Cyclization; Cysteine Endopeptidases/chemistry; Cysteine Endopeptidases/genetics; Models, Molecular; Molecular Sequence Data; Protein Conformation; Recombinant Proteins/genetics; Staphylococcus aureus/enzymology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Bacterial Proteins / Recombinant Proteins / Cysteine Endopeptidases / Protein Engineering / Aminoacyltransferases / Cystine Language: En Journal: FEBS Lett Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom

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