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Evaluation of urinary N-acetyl-beta-D-glucosaminidase as a marker of early renal damage in patients with type 2 diabetes mellitus.
Bouvet, Beatriz R; Paparella, Cecilia V; Arriaga, Sandra M M; Monje, Adriana L; Amarilla, Ana M; Almará, Adriana M.
Affiliation
  • Bouvet BR; Clinical Biochemistry Department, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
  • Paparella CV; Clinical Biochemistry Department, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
  • Arriaga SM; Clinical Biochemistry Department, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
  • Monje AL; Nephrology Service, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
  • Amarilla AM; Clinical Biochemistry Department, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
  • Almará AM; Clinical Biochemistry Department, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
Arq Bras Endocrinol Metabol ; 58(8): 798-801, 2014 Nov.
Article in En | MEDLINE | ID: mdl-25465599
OBJECTIVE: To evaluate the clinical usefulness of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion for the detection of early tubular damage in type 2 diabetes mellitus (T2DM). SUBJECTS AND METHODS: Thirty six patients with T2DM were divided into two groups based on urinary albumin to creatinine ratio (ACR): normoalbuminuria (ACR <30 mg/g; n=19) and microalbuminuria (ACR =30-300 mg/g; n=17). The following parameters were determined in both groups: urinary NAG and albumin, serum and urine creatinine, fasting plasma glucose and glycated hemoglobin (HbA1c). RESULTS: Urinary NAG levels [Units/g creatinine; median (range)] were significantly increased in microalbuminuria group [17.0 (5.9 - 23.3)] compared to normoalbuminuria group [4.4 (1.5 - 9.2)] (P<0.001). No differences between groups were observed in fasting glucose, HbA1c, serum creatinine levels and estimated glomerular filtration rates (eGFR). Urinary NAG positively correlated with ACR (r=0.628; p<0.0001), while no significant association was observed between NAG and glycemia, HbA1c, serum creatinine and eGFR. CONCLUSIONS: The increase of urinary NAG at the microalbuminuria stage of diabetic nephropathy (DN) suggests that tubular dysfunction is already present in this period. The significant positive association between urinary NAG excretion and ACR indicates the possible clinical application of urinary NAG as a complementary marker for early detection of DN in T2DM.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylglucosaminidase / Diabetes Mellitus, Type 2 / Diabetic Nephropathies / Albuminuria / Kidney Tubules Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Arq Bras Endocrinol Metabol Year: 2014 Document type: Article Affiliation country: Argentina Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylglucosaminidase / Diabetes Mellitus, Type 2 / Diabetic Nephropathies / Albuminuria / Kidney Tubules Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Arq Bras Endocrinol Metabol Year: 2014 Document type: Article Affiliation country: Argentina Country of publication: Brazil