Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienaymé reaction and their Hsp90 inhibitory activity.

Ren, Jing; Yang, Min; Liu, Hongchun; Cao, Danyan; Chen, Danqi; Li, Jian; Tang, Le; He, Jianhua; Chen, Yue-Lei; Geng, Meiyu; Xiong, Bing; Shen, Jingkang

Ren, Jing; Yang, Min; Liu, Hongchun; Cao, Danyan; Chen, Danqi; Li, Jian; Tang, Le; He, Jianhua; Chen, Yue-Lei; Geng, Meiyu; Xiong, Bing; Shen, Jingkang.

Affiliation

Ren J; Medicinal Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China. bxiong@simm.ac.cn.

Org Biomol Chem ; 13(5): 1531-5, 2015 Feb 07.

Article in En | MEDLINE | ID: mdl-25490978

Subject(s)

HSP90 Heat-Shock Proteins/antagonists & inhibitors; Pyrazines/chemistry; Pyrazines/pharmacology; Drug Design; HSP90 Heat-Shock Proteins/chemistry; Models, Molecular; Protein Conformation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / HSP90 Heat-Shock Proteins Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article

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