Discovery of multitarget-directed ligands against Alzheimer's disease through systematic prediction of chemical-protein interactions.

Fang, Jiansong; Li, Yongjie; Liu, Rui; Pang, Xiaocong; Li, Chao; Yang, Ranyao; He, Yangyang; Lian, Wenwen; Liu, Ai-Lin; Du, Guan-Hua

Fang, Jiansong; Li, Yongjie; Liu, Rui; Pang, Xiaocong; Li, Chao; Yang, Ranyao; He, Yangyang; Lian, Wenwen; Liu, Ai-Lin; Du, Guan-Hua.

Affiliation

Fang J; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, PR China.

J Chem Inf Model ; 55(1): 149-64, 2015 Jan 26.

Article in En | MEDLINE | ID: mdl-25531792

Subject(s)

Alzheimer Disease/drug therapy; Drug Discovery/methods; Quantitative Structure-Activity Relationship; Animals; Bayes Theorem; Cholinesterase Inhibitors/chemistry; Cholinesterase Inhibitors/pharmacology; Cyclin-Dependent Kinase 5/antagonists & inhibitors; Drug Evaluation, Preclinical/methods; Histamine H3 Antagonists/chemistry; Histamine H3 Antagonists/pharmacology; Humans; Ligands; Molecular Targeted Therapy; ROC Curve; Rats; Reproducibility of Results

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quantitative Structure-Activity Relationship / Drug Discovery / Alzheimer Disease Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Chem Inf Model Journal subject: INFORMATICA MEDICA / QUIMICA Year: 2015 Document type: Article Country of publication: United States

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