ZL-2, a cathelicidin-derived antimicrobial peptide, has a broad antimicrobial activity against gram-positive bacteria and gram-negative bacteria in vitro and in vivo.

Tu, Jiancheng; Wu, Geping; Zuo, Yun; Zhao, Lei; Wang, Shusheng

Tu, Jiancheng; Wu, Geping; Zuo, Yun; Zhao, Lei; Wang, Shusheng.

Affiliation

Tu J; Zhangjiagang First People's Hospital, Zhangjiagang, Suzhou, 215600, Jiangsu, China.
Wu G; Zhangjiagang First People's Hospital, Zhangjiagang, Suzhou, 215600, Jiangsu, China.
Zuo Y; Zhangjiagang First People's Hospital, Zhangjiagang, Suzhou, 215600, Jiangsu, China.
Zhao L; Institute of Frontier Medical Science, Jilin University, Changchun, 130033, Jilin, China.
Wang S; Zhangjiagang First People's Hospital, Zhangjiagang, Suzhou, 215600, Jiangsu, China. wang_shushengzjg@163.com.

Arch Pharm Res ; 38(10): 1802-9, 2015 Oct.

Article in En | MEDLINE | ID: mdl-25636224

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacteremia/drug therapy; Cathelicidins/pharmacology; Peptides/pharmacology; Animals; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/toxicity; Antimicrobial Cationic Peptides; Bacteremia/microbiology; Disease Models, Animal; Drug Synergism; Escherichia coli/isolation & purification; Escherichia coli Infections/drug therapy; Escherichia coli Infections/microbiology; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Humans; Mice; Mice, Inbred ICR; Peptides/administration & dosage; Peptides/toxicity; Spleen/cytology; Spleen/drug effects

Key words

Alloferon-1; Antimicrobial activity; Antimicrobial peptides; Bacteremia; ZL-2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Bacteremia / Cathelicidins / Anti-Bacterial Agents Limits: Animals / Humans Language: En Journal: Arch Pharm Res Year: 2015 Document type: Article Affiliation country: China Country of publication:

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