Potent anti-proliferative, pro-apoptotic activity of the Maytenus royleanus extract against prostate cancer cells: evidence in in-vitro and in-vivo models.

Shabbir, Maria; Syed, Deeba N; Lall, Rahul K; Khan, Muhammad Rashid; Mukhtar, Hasan

Shabbir, Maria; Syed, Deeba N; Lall, Rahul K; Khan, Muhammad Rashid; Mukhtar, Hasan.

Affiliation

Shabbir M; Department of Dermatology, University of Wisconsin, Madison, Wisconsin, United States of America; Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Syed DN; Department of Dermatology, University of Wisconsin, Madison, Wisconsin, United States of America.
Lall RK; Department of Dermatology, University of Wisconsin, Madison, Wisconsin, United States of America; Department of Food Science, University of Wisconsin, Madison, Wisconsin, United States of America.
Khan MR; Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Mukhtar H; Department of Dermatology, University of Wisconsin, Madison, Wisconsin, United States of America.

PLoS One ; 10(3): e0119859, 2015.

Article in En | MEDLINE | ID: mdl-25798940

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Cell Proliferation/drug effects; Maytenus/chemistry; Plant Extracts/pharmacology; Prostatic Neoplasms/drug therapy; Prostatic Neoplasms/pathology; Animals; Blotting, Western; Caspases/metabolism; Cell Cycle/drug effects; Cell Survival/drug effects; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; In Vitro Techniques; Male; Mice; Mice, Nude; Mitochondria/drug effects; Mitochondria/metabolism; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Plant Extracts / Apoptosis / Maytenus / Cell Proliferation / Antineoplastic Agents Type of study: Guideline / Prognostic_studies / Screening_studies Limits: Animals / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: Pakistan Country of publication: United States

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