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Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties.
Moraes, Carolina B; White, Karen L; Braillard, Stéphanie; Perez, Catherine; Goo, Junghyun; Gaspar, Luis; Shackleford, David M; Cordeiro-da-Silva, Anabela; Thompson, R C Andrew; Freitas-Junior, Lucio; Charman, Susan A; Chatelain, Eric.
Affiliation
  • Moraes CB; Center for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea.
  • White KL; Centre for Drug Candidate Optimisation, Monash University, Parkville, Victoria, Australia.
  • Braillard S; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
  • Perez C; Murdoch University, Murdoch, WA, Australia.
  • Goo J; Center for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea.
  • Gaspar L; Center for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea Faculdade de Farmácia e Instituto de Biologia Molecular Celular da Universidade do Porto, Porto, Portugal.
  • Shackleford DM; Centre for Drug Candidate Optimisation, Monash University, Parkville, Victoria, Australia.
  • Cordeiro-da-Silva A; Faculdade de Farmácia e Instituto de Biologia Molecular Celular da Universidade do Porto, Porto, Portugal.
  • Thompson RC; Murdoch University, Murdoch, WA, Australia.
  • Freitas-Junior L; Center for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Bundang-gu, Seongnam-Si, Gyeonggi-do, South Korea.
  • Charman SA; Centre for Drug Candidate Optimisation, Monash University, Parkville, Victoria, Australia.
  • Chatelain E; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland echatelain@dndi.org.
Antimicrob Agents Chemother ; 59(6): 3645-7, 2015.
Article in En | MEDLINE | ID: mdl-25845874
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / Nifurtimox Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Antimicrob Agents Chemother Year: 2015 Document type: Article Affiliation country: South Korea Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / Nifurtimox Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Antimicrob Agents Chemother Year: 2015 Document type: Article Affiliation country: South Korea Country of publication: United States