Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4.

Lee, Jae-Wook; Ryu, Yun-Kyoung; Ji, Young-Hoon; Kang, Joo Hyun; Moon, Eun-Yi

Lee, Jae-Wook; Ryu, Yun-Kyoung; Ji, Young-Hoon; Kang, Joo Hyun; Moon, Eun-Yi.

Affiliation

Lee JW; Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
Ryu YK; Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
Ji YH; Research Center for Radiotherapy, Korea Institute of Radiological and Medical Science, Seoul 139-709, Korea.
Kang JH; Molecular Imaging Research Center, Korea Institute of Radiological and Medical Science, Seoul 139-709, Korea.
Moon EY; Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.

Oncotarget ; 6(12): 9820-33, 2015.

Article in En | MEDLINE | ID: mdl-25888632

Subject(s)

GTP Phosphohydrolases/metabolism; Gene Expression Regulation, Neoplastic; Oxygen/chemistry; Telomere-Binding Proteins/metabolism; Thymosin/metabolism; rac1 GTP-Binding Protein/metabolism; Aminoquinolines/chemistry; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Enzyme Activation; HeLa Cells; Humans; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neuropeptides/metabolism; Pyrimidines/chemistry; Shelterin Complex; Signal Transduction; Tumor Microenvironment; Two-Hybrid System Techniques

Key words

Rac1-GTPase; Rap1-GTPase; cancer cell migration; thymosin beta-4; tumor metastasis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Thymosin / Gene Expression Regulation, Neoplastic / Rac1 GTP-Binding Protein / Telomere-Binding Proteins / GTP Phosphohydrolases Limits: Animals / Humans / Male Language: En Journal: Oncotarget Year: 2015 Document type: Article Country of publication: United States

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