PBK/TOPK enhances aggressive phenotype in prostate cancer via ß-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion.

Brown-Clay, Joshua D; Shenoy, Deepika N; Timofeeva, Olga; Kallakury, Bhaskar V; Nandi, Asit K; Banerjee, Partha P

Brown-Clay, Joshua D; Shenoy, Deepika N; Timofeeva, Olga; Kallakury, Bhaskar V; Nandi, Asit K; Banerjee, Partha P.

Affiliation

Brown-Clay JD; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Shenoy DN; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Timofeeva O; Departments of Oncology and Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Kallakury BV; Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.
Nandi AK; Current address: Cockeysville, Maryland.
Banerjee PP; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.

Oncotarget ; 6(17): 15594-609, 2015 Jun 20.

Article in En | MEDLINE | ID: mdl-25909225

Subject(s)

Biomarkers, Tumor/metabolism; Mitogen-Activated Protein Kinase Kinases/metabolism; Prostatic Neoplasms/pathology; TCF Transcription Factors/metabolism; beta Catenin/metabolism; Abdominal Neoplasms/secondary; Biomarkers, Tumor/genetics; Bone Neoplasms/secondary; Cell Line, Tumor; Cell Movement; Humans; Lymphatic Metastasis/pathology; Male; Matrix Metalloproteinase 2/biosynthesis; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 9/biosynthesis; Matrix Metalloproteinase 9/genetics; Mitogen-Activated Protein Kinase Kinases/genetics; Neoplasm Invasiveness; Promoter Regions, Genetic/genetics; Signal Transduction

Key words

PBK/TOPK; cell invasion; metastasis; prostate cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Biomarkers, Tumor / Mitogen-Activated Protein Kinase Kinases / Beta Catenin / TCF Transcription Factors Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Oncotarget Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States

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