Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer.

To, Kenneth K W; Poon, Daniel C; Wei, Yuming; Wang, Fang; Lin, Ge; Fu, Liwu

To, Kenneth K W; Poon, Daniel C; Wei, Yuming; Wang, Fang; Lin, Ge; Fu, Liwu.

Affiliation

To KK; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Poon DC; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Wei Y; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Wang F; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
Lin G; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Fu L; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.

Br J Pharmacol ; 172(16): 4089-106, 2015 Aug.

Article in En | MEDLINE | ID: mdl-25988710

Subject(s)

ATP-Binding Cassette Transporters/genetics; Aminoquinolines/pharmacology; Aniline Compounds/pharmacology; Antineoplastic Agents/pharmacology; ErbB Receptors/antagonists & inhibitors; Lung Neoplasms/genetics; Multidrug Resistance-Associated Proteins/genetics; Neoplasm Proteins/genetics; Protein Kinase Inhibitors/pharmacology; ATP Binding Cassette Transporter, Subfamily B/genetics; ATP Binding Cassette Transporter, Subfamily B/metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/metabolism; Adenosine Triphosphatases/metabolism; Cell Line, Tumor; Drug Resistance, Neoplasm/drug effects; Humans; Hyperthermia, Induced; Lung Neoplasms/drug therapy; Lung Neoplasms/metabolism; Neoplasm Proteins/metabolism; Topotecan/pharmacology; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP-Binding Cassette Transporters / Multidrug Resistance-Associated Proteins / Protein Kinase Inhibitors / ErbB Receptors / Aminoquinolines / Aniline Compounds / Lung Neoplasms / Neoplasm Proteins / Antineoplastic Agents Limits: Humans Language: En Journal: Br J Pharmacol Year: 2015 Document type: Article Affiliation country: China Country of publication: United kingdom

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