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Anti-inflammatory effect of water extracts of Graptopetalum paraguayense supplementation in subjects with metabolic syndrome: a preliminary study.
Chen, Shu-Ju; Yen, Chi-Hua; Liu, Jen-Tzu; Tseng, Yu-Fen; Lin, Ping-Ting.
Affiliation
  • Chen SJ; Department of Health Food, Chung Chou University of Science and Technology, Changhua, 51003, Taiwan.
  • Yen CH; Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan.
  • Liu JT; School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan.
  • Tseng YF; Center for Education and Research on Geriatrics and Gerontology, Chung Shan Medical University, Taichung, 40201, Taiwan.
  • Lin PT; School of Nutrition, Chung Shan Medical University, Taichung, 40201, Taiwan.
J Sci Food Agric ; 96(5): 1772-6, 2016 Mar 30.
Article in En | MEDLINE | ID: mdl-26036956
BACKGROUND: Many studies have demonstrated that Graptopetalum paraguayense has good antioxidant ability; however, few studies have examined its anti-inflammatory effect. The study aimed to investigate the anti-inflammatory effects of water extracts of G. paraguayense (WGP, 4 g day(-1)) in subjects with metabolic syndrome (MS). Intervention was administered for 12 weeks. Levels of inflammatory markers [high sensitivity C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6)] and antioxidant enzymes activities were measured. RESULTS: Forty-two subjects completed the 12 week intervention study (placebo, n = 19; WGP, n = 23). After 12 weeks supplementation, subjects in WGP group had significantly lower levels of inflammatory markers than the baseline (P < 0.05) and the placebo group (CRP, P = 0.07; TNF-α, P = 0.04; IL-6, P = 0.03). The changes in levels of the inflammatory markers were significantly decreased in WGP group (CRP, P = 0.04; TNF-α, P = 0.06; IL-6, P = 0.01) compared to the placebo group. Levels of inflammatory markers were significantly negatively correlated with the antioxidant enzymes activities after supplementation. CONCLUSION: This study demonstrated a significant reduction in inflammatory status in MS after WGP supplementation. WGP may exert an anti-inflammatory effect on MS in addition to its antioxidant ability.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Dietary Supplements / Crassulaceae / Metabolic Syndrome / Anti-Inflammatory Agents Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do sul / Paraguay Language: En Journal: J Sci Food Agric Year: 2016 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Dietary Supplements / Crassulaceae / Metabolic Syndrome / Anti-Inflammatory Agents Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do sul / Paraguay Language: En Journal: J Sci Food Agric Year: 2016 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom