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[Relationship between blood pressure, heart rate and cardiac autonomic dysfunction in non-diabetic obese patients]. / Relation entre pression artérielle, fréquence cardiaque et dysfonction autonome cardiaque chez les obèses non diabétiques.
Banu, I; Nguyen, M T; Hamo-Tchatchouang, E; Cosson, E; Valensi, P.
Affiliation
  • Banu I; Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France. Electronic address: isabela.banu@jvr.aphp.fr.
  • Nguyen MT; Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
  • Hamo-Tchatchouang E; Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
  • Cosson E; Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
  • Valensi P; Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
Ann Cardiol Angeiol (Paris) ; 64(3): 139-44, 2015 Jun.
Article in Fr | MEDLINE | ID: mdl-26047878
RATIONALE: Some studies suggest that a high heart rate (HR) would be predictive of the incidence of an elevated blood pressure (BP). Cardiac autonomic dysfunction (CAD) affects a high proportion of obese patients. CAD could be involved in BP increase. Our aim was to examine the relationship between CAD, HR and BP in obese patients without known diabetes. PATIENTS AND METHODS: We included 428 overweight or obese patients. CAD was assessed by analyzing HR variations during three standard tests (Valsalva, deep breathing, lying-to-standing), which are mostly dependent on vagal control. An oral load in glucose was performed and the Matsuda index was calculated. RESULTS: The population was separated in 4 groups according to the grade of CAD (no or only one abnormal test, 2 or 3 abnormal tests) and HR (< or ≥ 75 bpm). Age was similar in the four groups. Systolic (P=0.05), diastolic (P<0.005) and mean BP (P<0.001) differed significantly between the 4 groups, and was the highest in the group of patients who had 2 or 3 abnormal tests and HR ≥ 75 bpm. Matsuda index differed across the groups (P=0.018) and was the lowest in this group. CONCLUSION: These data indicate that among overweight or obese patients with a defect in cardiac vagal activity BP is elevated only in those with a high heart rate, which is indicative of a more marked insulin resistance and probably an excess in sympathetic activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autonomic Nervous System / Blood Pressure / Heart / Heart Rate / Obesity Limits: Adult / Female / Humans / Male Language: Fr Journal: Ann Cardiol Angeiol (Paris) Year: 2015 Document type: Article Country of publication: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autonomic Nervous System / Blood Pressure / Heart / Heart Rate / Obesity Limits: Adult / Female / Humans / Male Language: Fr Journal: Ann Cardiol Angeiol (Paris) Year: 2015 Document type: Article Country of publication: France