Trichilia catigua ethyl-acetate fraction protects against cognitive impairments and hippocampal cell death induced by bilateral common carotid occlusion in mice.

Truiti, Manuela Torrado; Soares, LígiaMendes; Longhini, Renata; Milani, Humberto; Nakamura, Celso Vataru; Mello, João Carlos P; de Oliveira, Rúbia Marsia Weffort

Truiti, Manuela Torrado; Soares, LígiaMendes; Longhini, Renata; Milani, Humberto; Nakamura, Celso Vataru; Mello, João Carlos P; de Oliveira, Rúbia Marsia Weffort.

Affiliation

Truiti MT; Laboratory of Neuropsychopharmacology, Department of Pharmacology and Therapeutics, Maringá 87020-900, Paraná, Brazil.
Soares L; Laboratory of Neuropsychopharmacology, Department of Pharmacology and Therapeutics, Maringá 87020-900, Paraná, Brazil.
Longhini R; Laboratory of Pharmaceutical Biology, Palafito, Maringá, Brazil.
Milani H; Laboratory of Neuropsychopharmacology, Department of Pharmacology and Therapeutics, Maringá 87020-900, Paraná, Brazil.
Nakamura CV; Laboratory of Microbiology, Universidade Estadual de Maringá, Av. Colombo, 5790, Maringá 87020-900, Paraná, Brazil.
Mello JC; Laboratory of Pharmaceutical Biology, Palafito, Maringá, Brazil.
de Oliveira RM; Laboratory of Neuropsychopharmacology, Department of Pharmacology and Therapeutics, Maringá 87020-900, Paraná, Brazil. Electronic address: rmmwoliveira@uem.br.

J Ethnopharmacol ; 172: 232-7, 2015 Aug 22.

Article in En | MEDLINE | ID: mdl-26099636

Subject(s)

Cognition Disorders/drug therapy; Meliaceae/chemistry; Plant Extracts/pharmacology; Acetates/chemistry; Animals; Brain Ischemia/complications; Brain Ischemia/drug therapy; Brain Ischemia/pathology; Carotid Artery, Common/pathology; Carotid Stenosis/complications; Cell Death/drug effects; Cognition Disorders/etiology; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus/pathology; Male; Maze Learning/drug effects; Mice; Plant Extracts/administration & dosage

Key words

ANOVA=analysis of variance; BCCAO=bilateral common carotid occlusion; Bilateral common carotid occlusion; CE=crude extract; Cognition; DPPH=2,2-diphenyl-1-picryl-hydrazyl; EAF=Trichilia catigua ethyl-acetate fraction; EPC=epicatechin; HPLC=high performance liquid chromatography; Morris water maze; Neurodegeneration; OGD=oxygen and glucose deprivation; PB2=procyanidin B2; ROS=reactive oxygen species; SOD=superoxide dismutase; TFA=trifluoroacetic acid; TGCI=transient global cerebral ischemia; Trichilia catigua ethyl-acetate fraction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Cognition Disorders / Meliaceae Type of study: Etiology_studies Limits: Animals Language: En Journal: J Ethnopharmacol Year: 2015 Document type: Article Affiliation country: Brazil Country of publication: Ireland

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