Thermodynamics of binding of a sulfonamide inhibitor to metal-mutated carbonic anhydrase as studied by affinity capillary electrophoresis.

Sato, Yosuke; Hoshino, Hitoshi; Iki, Nobuhiko

Sato, Yosuke; Hoshino, Hitoshi; Iki, Nobuhiko.

Affiliation

Sato Y; Graduate School of Environmental Studies, Tohoku University, 6-6-07 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan.
Hoshino H; Graduate School of Environmental Studies, Tohoku University, 6-6-07 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan.
Iki N; Graduate School of Environmental Studies, Tohoku University, 6-6-07 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan. Electronic address: iki@m.tohoku.ac.jp.

J Inorg Biochem ; 150: 133-8, 2015 Sep.

Article in En | MEDLINE | ID: mdl-26112153

Subject(s)

Carbonic Anhydrase II/antagonists & inhibitors; Carbonic Anhydrase II/chemistry; Carbonic Anhydrase Inhibitors/chemistry; Metals, Heavy/chemistry; Naphthalenesulfonates/metabolism; Sulfonamides/metabolism; Animals; Carbonic Anhydrase Inhibitors/chemical synthesis; Cattle; Electrophoresis, Capillary; Models, Chemical; Naphthalenesulfonates/chemical synthesis; Naphthalenesulfonates/chemistry; Protein Binding; Sulfonamides/chemical synthesis; Sulfonamides/chemistry; Thermodynamics

Key words

Affinity capillary electrophoresis; Carbonic anhydrase; Metal-substituted enzymes; Sulfonamides; Zn(II)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Carbonic Anhydrase Inhibitors / Metals, Heavy / Carbonic Anhydrase II / Naphthalenesulfonates Limits: Animals Language: En Journal: J Inorg Biochem Year: 2015 Document type: Article Affiliation country: Japan Country of publication: United States

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