Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.

Wang, Zemin; Neal, Barbara H; Lamb, James C; Klaunig, James E

Wang, Zemin; Neal, Barbara H; Lamb, James C; Klaunig, James E.

Affiliation

Wang Z; *Department of Environmental Health, Indiana University Bloomington, Indiana 47405; and.
Neal BH; Center for Toxicology and Mechanistic Biology, Exponent Inc., Alexandria, Virginia 22314.
Lamb JC; Center for Toxicology and Mechanistic Biology, Exponent Inc., Alexandria, Virginia 22314.
Klaunig JE; *Department of Environmental Health, Indiana University Bloomington, Indiana 47405; and jklauni@indiana.edu.

Toxicol Sci ; 147(2): 549-61, 2015 Oct.

Article in En | MEDLINE | ID: mdl-26187448

Subject(s)

Carcinogens/toxicity; Liver Neoplasms, Experimental/chemically induced; Toxaphene/toxicity; Animals; Carcinogens/administration & dosage; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Gene Expression Regulation/drug effects; Lipid Peroxidation/drug effects; Liver/drug effects; Male; Mice; Mice, Inbred Strains; Receptors, Aryl Hydrocarbon/drug effects; Receptors, Aryl Hydrocarbon/metabolism; Receptors, Cytoplasmic and Nuclear/drug effects; Receptors, Cytoplasmic and Nuclear/metabolism; Toxaphene/administration & dosage

Key words

constitutive androstane receptor; constitutive androstane receptor knockout mice; liver tumor promotion; nongenotoxic; toxaphene

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxaphene / Carcinogens / Liver Neoplasms, Experimental Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Document type: Article Country of publication: United States

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