The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential.

Craney, Arryn; Romesberg, Floyd E

Craney, Arryn; Romesberg, Floyd E.

Affiliation

Craney A; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Romesberg FE; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Bioorg Med Chem Lett ; 25(21): 4761-4766, 2015 Nov 01.

Article in En | MEDLINE | ID: mdl-26276537

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacteria/drug effects; Bacteria/enzymology; Enzyme Inhibitors/pharmacology; Membrane Proteins/antagonists & inhibitors; Anti-Bacterial Agents/chemistry; Enzyme Inhibitors/chemistry; Membrane Proteins/metabolism; Molecular Conformation; Serine Endopeptidases/metabolism

Key words

Antibiotic; Arylomycin; Protein secretion; SPase; Virulence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Enzyme Inhibitors / Membrane Proteins / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: United States

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