Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).

Lu, Sizhao; Mott, Justin L; Harrison-Findik, Duygu Dee

Lu, Sizhao; Mott, Justin L; Harrison-Findik, Duygu Dee.

Affiliation

Lu S; From the Department of Biochemistry and Molecular Biology and.
Mott JL; From the Department of Biochemistry and Molecular Biology and.
Harrison-Findik DD; the Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5820 dharrisonfindik@unmc.edu.

J Biol Chem ; 290(40): 24178-89, 2015 Oct 02.

Article in En | MEDLINE | ID: mdl-26304124

Subject(s)

ELAV-Like Protein 1/metabolism; Fatty Acids/chemistry; Fatty Liver/metabolism; Hepcidins/metabolism; Palmitic Acid/chemistry; RNA Processing, Post-Transcriptional; 3' Untranslated Regions; Animals; Cell Line, Tumor; Cell Nucleus/metabolism; Cytoplasm/metabolism; Hep G2 Cells; Hepcidins/genetics; Humans; Iron/chemistry; Mice; Mutagenesis; Mutation; Phosphorylation; Protein Binding; Protein Transport; RNA, Messenger/metabolism; RNA, Small Interfering/metabolism; Signal Transduction

Key words

AU-rich element; HuR; fatty acid; fatty liver disease; hepcidin; iron; mRNA decay; microRNA (miRNA); post-transcriptional regulation; protein kinase C (PKC)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Processing, Post-Transcriptional / Palmitic Acid / Fatty Acids / Fatty Liver / Hepcidins / ELAV-Like Protein 1 Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2015 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google