Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo.

Leong, Pou Kuan; Ko, Kam Ming

Leong, Pou Kuan; Ko, Kam Ming.

Affiliation

Leong PK; Division of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China.
Ko KM; Division of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China.

Biofactors ; 41(5): 314-23, 2015.

Article in En | MEDLINE | ID: mdl-26307448

Subject(s)

Inflammasomes/drug effects; Lignans/pharmacology; Polycyclic Compounds/pharmacology; Thioredoxins/metabolism; Alum Compounds/toxicity; Animals; Caspase 1/metabolism; Cell Line; Cells, Cultured; Cyclooctanes/pharmacology; Cyclooctanes/therapeutic use; Female; Interleukin-1beta/metabolism; Lignans/therapeutic use; Macrophages/drug effects; Macrophages/metabolism; Mice; Mice, Inbred ICR; Peritonitis/chemically induced; Peritonitis/drug therapy; Peritonitis/metabolism; Polycyclic Compounds/therapeutic use; Reactive Oxygen Species/metabolism

Key words

caspase 1; inflammasome; macrophage; schisandrin B; thioredoxin

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Compounds / Thioredoxins / Lignans / Inflammasomes Limits: Animals Language: En Journal: Biofactors Journal subject: BIOQUIMICA Year: 2015 Document type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google