SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.

Gorgani-Firuzjaee, Sattar; Meshkani, Reza

Gorgani-Firuzjaee, Sattar; Meshkani, Reza.

Affiliation

Gorgani-Firuzjaee S; Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R Iran.
Meshkani R; Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I.R Iran. Electronic address: rmeshkani@tums.ac.ir.

Free Radic Biol Med ; 89: 679-89, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26456051

Subject(s)

Cholesterol, VLDL/biosynthesis; Insulin Resistance/physiology; Lipogenesis/physiology; Phosphoric Monoester Hydrolases/metabolism; Signal Transduction/physiology; AMP-Activated Protein Kinases/metabolism; Blotting, Western; Glucose/metabolism; Hep G2 Cells; Humans; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Reactive Oxygen Species/metabolism; Real-Time Polymerase Chain Reaction; Sterol Regulatory Element Binding Protein 1/metabolism; TOR Serine-Threonine Kinases/metabolism

Key words

De-novo lipogenesis; HepG2; Hyperglycemia; Insulin resistance; Liver; SH2 domain containing inositol 5-phosphatase (SHIP2); VLDL

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Cholesterol, VLDL / Signal Transduction / Phosphoric Monoester Hydrolases / Lipogenesis Limits: Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2015 Document type: Article Country of publication: United States

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