Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Eur J Med Chem
; 105: 1-38, 2015 Nov 13.
Article
in En
| MEDLINE
| ID: mdl-26469743
ABSTRACT
Breast cancer, an emerging disease among the women population, occurs due to overexpression of estrogens. The enzyme aromatase plays a key rate limiting role in the biosynthesis of estrogens. Certain clinical advantages of the use of exemestane, a steroidal aromatase inhibitor over non-steroidal aromatase inhibitors have drawn the attention of researchers for the development of novel steroidal aromatase inhibitors.The current review is a humble attempt to compile the reports by various researchers till date on the synthesis of steroidal aromatase inhibitors. It has been tried to encompass the structural modifications carried out by various researchers in the steroid ring system by taking up the functional group modifications on rings A, B, ring A/B junction, ring-D, ring modifications, bridged derivatives and heterocyclic ring-fused derivatives in a systematic way.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Aromatase
/
Drug Design
/
Aromatase Inhibitors
Limits:
Female
/
Humans
Language:
En
Journal:
Eur J Med Chem
Year:
2015
Document type:
Article