Pharmacokinetic aspects and in vitro-in vivo correlation potential for lipid-based formulations.
Acta Pharm Sin B
; 4(5): 333-49, 2014 Oct.
Article
in En
| MEDLINE
| ID: mdl-26579403
ADME, absorption/distribution/metabolism/elimination; AUC, area under the curve; BCS, biopharmaceutics classification system; BDDCS, biopharmaceutics drug disposition classification system; CACO, human epithelial colorectal adenocarcinoma cells; CMC, critical micellar concentration; CYP, cytochrome; Cmax, maximum plasma concentration; DDS, drug delivery systems; Efflux transporters; FaSSGF, fasted-state simulated gastric fluid; FaSSIF, fasted-state simulated intestinal fluid; FeSSIF, fed-state simulated intestinal fluid; Food effect; GIT, gastrointestinal tract; IVIVC; IVIVC, in vitro in vivo correlation; LCT, long chain triglyceride; LFCS, lipid formulation classification system; Lipolysis; Lymphatic delivery; MCT, medium chain triglyceride; MDCK, MadinDarby canine kidney cells; NCE, new chemical entity; P-app, apparent permeability; P-gp, permeability glycoprotein; Pharmacokinetics; SCT, short chain triglyceride; SEDDS, self-emulsifying drug delivery system; SIF, simulated intestinal fluid; SMEDDS, self-microemulsifying drug delivery system; SNEDDS, self-nanoemulsifying drug delivery system; Vit E, vitamin E; log P, n-octanol/water partition coefficient
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Acta Pharm Sin B
Year:
2014
Document type:
Article
Affiliation country:
India
Country of publication:
Netherlands