Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.

Jeong, Hye Rin; An, Seong Soo A

Jeong, Hye Rin; An, Seong Soo A.

Affiliation

Jeong HR; Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Gyeonggi-do, Republic of Korea.
An SS; Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Gyeonggi-do, Republic of Korea.

Clin Interv Aging ; 10: 1873-9, 2015.

Article in En | MEDLINE | ID: mdl-26604727

Subject(s)

Diabetes Mellitus, Type 2/physiopathology; Insulin-Secreting Cells/metabolism; Islet Amyloid Polypeptide/metabolism; Aging/physiology; Amyloid/biosynthesis; Amyloid beta-Peptides/metabolism; Animals; Cell Death; Copper/metabolism; Heparin/pharmacology; Humans; Hydrogen-Ion Concentration; Mice; Mutation; Nondisjunction, Genetic; Proprotein Convertase 2/metabolism; Rats; Rifampin/pharmacology

Key words

IAPP; T2DM; amyloid aggregation; causative factor; islet amyloid polypeptide; toxic oligomer; type 2 diabetes mellitus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / Islet Amyloid Polypeptide Limits: Animals / Humans Language: En Journal: Clin Interv Aging Journal subject: GERIATRIA Year: 2015 Document type: Article Country of publication: New Zealand

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