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Twenty-two-item Sino-Nasal Outcome Test in a control population: a cross-sectional study and systematic review.
Farhood, Zachary; Schlosser, Rodney J; Pearse, Madeline E; Storck, Kristina A; Nguyen, Shaun A; Soler, Zachary M.
Affiliation
  • Farhood Z; Department of Otolaryngology-Head and Neck Surgery, The Medical University of South Carolina, Charleston, SC.
  • Schlosser RJ; Department of Otolaryngology-Head and Neck Surgery, The Medical University of South Carolina, Charleston, SC.
  • Pearse ME; Department of Otolaryngology-Head and Neck Surgery, The Medical University of South Carolina, Charleston, SC.
  • Storck KA; Department of Otolaryngology-Head and Neck Surgery, The Medical University of South Carolina, Charleston, SC.
  • Nguyen SA; Department of Otolaryngology-Head and Neck Surgery, The Medical University of South Carolina, Charleston, SC.
  • Soler ZM; Department of Otolaryngology-Head and Neck Surgery, The Medical University of South Carolina, Charleston, SC.
Int Forum Allergy Rhinol ; 6(3): 271-7, 2016 Mar.
Article in En | MEDLINE | ID: mdl-26610073
BACKGROUND: The 22-item Sino-Nasal Outcome Test (SNOT-22) is a commonly utilized outcome measure for chronic rhinosinusitis (CRS). However, what constitutes a normal score remains poorly defined. The goal of this study was to evaluate SNOT-22 scores in a control population without CRS and perform a systematic review and meta-analysis of "normal" values. METHODS: Ninety-nine subjects without CRS were enrolled, with 95 fully completing the SNOT-22 questionnaire. Multivariable linear regression was used to determine whether demographic factors or medical comorbidities influence SNOT-22 scores in a population without CRS. A systematic literature search was performed, identifying studies that evaluated the SNOT-22 in a non-CRS population and estimates for SNOT-22 values were pooled. RESULTS: Thirty-six males and 59 females were included in the primary analysis with a mean age of 53.4 ± 17.3 years (range, 18-88 years). The mean SNOT-22 score was 16.4 ± 15.2. Asthma (p = 0.003) and depression (p = 0.002) were found to be independent predictors of higher SNOT-22 scores. Thirteen articles were identified in the literature search and 1 was provided via author correspondence, with 10 reporting sufficient data to be included in the meta-analysis. Weighted mean SNOT-22 score was 11 ± 9.4 (n = 1517). Our data differed significantly from published data (mean difference = 5.4; 95% confidence interval [CI], 3.4 to 7.5; p < 0.0001) likely owing to differences in comorbidities. CONCLUSION: SNOT-22 scores vary in non-CRS populations depending upon the group queried. Asthma and depression are associated with higher SNOT-22 scores and should be considered when determining what constitutes a normal value.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Sinusitis / Rhinitis / Surveys and Questionnaires / Depression Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Aspects: Patient_preference Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Int Forum Allergy Rhinol Year: 2016 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Sinusitis / Rhinitis / Surveys and Questionnaires / Depression Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Aspects: Patient_preference Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Int Forum Allergy Rhinol Year: 2016 Document type: Article Country of publication: United States